Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …
severe neural injuries, and is one of the leading causes of death and disability worldwide …
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda… - Nature, 2022 - nature.com
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
Trends in kinase drug discovery: targets, indications and inhibitor design
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
LK Billingham, JS Stoolman, K Vasan… - Nature …, 2022 - nature.com
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …
Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study
Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute
respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of …
respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas of …
[HTML][HTML] The role of IL-1β and TNF-α in intervertebral disc degeneration
Y Wang, M Che, J Xin, Z Zheng, J Li, S Zhang - Biomedicine & …, 2020 - Elsevier
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …
Cytokines in inflammatory disease
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …
Numerous studies have implicated that inflammatory cytokines exert important effects with …