Heterogeneous assay for pyrophosphate detection

JGK Williams - US Patent 6,232,075, 2001 - Google Patents
Nucleotide triphosphate probes containing a fluorophore attached to the β-phosphate and a
quencher moiety sufficiently proximal to the fluorophore moiety for use in pyrophosphate …

Apparatus and method for detection and discrimination molecular object

HC Chen, MC Li, CS Chu, YT Li, CF Chiou - US Patent 9,778,188, 2017 - Google Patents
6, 210, 973 B1 6, 232, 075 B1 6, 255, 083 B1 6, 306, 607 B2 6, 344, 653 B1 6, 362, 002 B1
6, 374, 019 B1 6, 413, 792 B1 6, 618, 536 B1 6, 762, 048 B2 6, 917, 726 B2 6, 946, 249 B2 …

Apparatus for single-molecule detection

CF Chiou, RY Tsai, YT Li, CT Shih, MC Li… - US Patent …, 2014 - Google Patents
An apparatus for detecting an object capable of emitting light. The apparatus includes a light
source and a waveguide. The waveguide includes a core layer and a first cladding layer. At …

Labeled nucleotide phosphate (NP) probes

J Korlach, WW Webb, M Levene, S Turner… - US Patent …, 2009 - Google Patents
The present invention is directed to a method of sequencing a target nucleic acid molecule
having a plurality of bases. In its principle, the temporal order of base additions during the …

Single molecule detection systems and methods

JGK Williams, GR Bashford - US Patent 7,118,907, 2006 - Google Patents
A microfluidic system is provided that includes a substrate, a first microchannel disposed in
the substrate for providing a reactant to a reaction zone, a second microchannel disposed in …

Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

P Williams - US Patent 9,212,393, 2015 - Google Patents
This patent application is a continuation of Ser. No. 12/969, 872 filed Dec. 16, 2010, now US
Pat. No. 9,096,898 which is a continuation of Ser. No. 11/929,141 filed Oct. 30, 2007, now …

Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate

LG Lee, BB Rosenblum - US Patent 6,017,702, 2000 - Google Patents
US6017702A - Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
- Google Patents US6017702A - Chain-termination type nucleic acid sequencing method …

Ultrafast sequencing of biological polymers using a labeled nanopore

M Huber - US Patent 8,771,491, 2014 - Google Patents
Methods and systems for sequencing a biological molecule or polymer, eg, a nucleic acid,
are provided. One or more donor labels, which are attached to a pore or nanopore, may be …

Heterogeneous assay for pyrophosphate

JGK Williams - US Patent 6,306,607, 2001 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
26809573&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Method for analyzing nucleic acid reactions

DC Schwartz, T Wu - US Patent 6,607,888, 2003 - Google Patents
The present invention relates to methods for analyzing nucleic acid reactions in general and
transcription reactions in particular. The method utilizes individual nucleic acid molecules …