Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic
landscape associated with cancer, with a minimal number of genes exhibiting dual-context …

Neoplastic progression involves complex interactions between cancer cells and the
surrounding stromal milieu, fostering microenvironments that crucially drive tumor …

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) involves a
significant accumulation of cancer-associated fibroblasts (CAFs) as part of the host response …

Deficiency of DNA repair pathways drives the development of colorectal cancer. However,
the role of the base excision repair (BER) pathway in colorectal cancer initiation remains …

In a recent study published in Cancer Discovery, Hsu and colleagues employ an elegant
combination of single-cell and bulk RNA sequencing experiments from mouse and human …

Macrophages and tumour stroma cells account for the main cellular components in the
tumour microenvironment (TME). Current advancements in single-cell analysis have …

With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the
development of innovative treatment strategies is increasingly vital. This review underscores …

Colon cancer is relatively asymptomatic in the early stages, the manifestations appearing
and intensifying with the evolution of the disease, especially when associated with local …

Interactions between cells in the tumor microenvironment (TME) shape cancer progression
and patient outcomes. To gain new insights into how the TME influences cancer outcomes …

Despite advancements in targeted and immunotherapies, lung cancer remains the leading
cause of cancer-related deaths in both men and women worldwide. At 85%, non-small cell …