The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …

The primary function of myeloid cells is to protect the host from infections. However, during
cancer progression or states of chronic inflammation, these cells develop into myeloid …

The immune system is remarkably responsive to a myriad of invading microorganisms and
provides continuous surveillance against tissue damage and developing tumor cells. To …

Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal
overload of lipid peroxides, in cancer therapy is impeded by our limited understanding of the …

Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor
recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM) …

Widespread coronavirus disease (COVID)-19 is causing pneumonia, respiratory and
multiorgan failure in susceptible individuals. Dysregulated immune response marks severe …

A chronic low-grade inflammation is one of the hallmarks of the aging process. This
gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is …

Formerly considered as a passive process, the resolution of acute inflammation is now
recognized as an active host response, with a cascade of coordinated cellular and …

Alarmins, sequestered self-molecules containing damage-associated molecular patterns,
are released during tissue injury to drive innate immune cell proinflammatory responses …

Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-
associated neutrophils display many roles during cancer progression. Several tumor …