Robust and effective T cell–mediated immune responses require proper allocation of
metabolic resources through metabolic pathways to sustain the energetically costly immune …

A paucity of knowledge exists regarding the metabolic needs of a number of immune cells
involved in the pathogenesis of SLE, including myeloid cells and B cells. Nonetheless, SLE …

Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has
caused the death of nearly six million people worldwide. Emerging data have identified a …

Neutrophils, the most abundant circulating leukocytes in human, play an indispensable role
in the innate immune response to microbial infections. However, the contribution of tumor …

Cancer progression is marked by the infiltration of immunosuppressive cells, such as tumor-
associated macrophages (TAMs), regulatory T lymphocytes (Tregs), and myeloid-derived …

Increasing evidence support that cellular amino acid metabolism shapes the fate of immune
cells; however, whether aspartate metabolism dictates macrophage function is still …

In the tumor microenvironment, arginine is metabolized by arginase-expressing myeloid
cells. This arginine depletion profoundly inhibits T cell functions and is crucially involved in …

Severe fever with thrombocytopenia syndrome (SFTS) caused by a recently identified
bunyavirus, SFTSV, is an emerging infectious disease with extensive geographical …

Dendritic cell-derived exosomes (Dex) have overcome the disadvantages associated with
dendritic cell (DC) vaccines, such as cost effectiveness, stability, and sensitivity to the …

Cryptococcus neoformans is a leading cause of invasive fungal infections among
immunocompromised patients. However, the cellular constituents of the innate immune …