6-Gingerol (6-G) is the main bioactive component in Ginger (Zingiber officinale Roscoe). The
aim of this study was to explore the contribution of macrophage polarization in 6-G …

Immune checkpoint inhibitors have ushered in a new era of cancer treatment by increasing
the likelihood of long-term survival for patients with metastatic disease and by introducing …

Amino acids are essential for protein synthesis, epigenetic modification through the
methylation of histones, and the maintenance of a controlled balance of oxidoreduction via …

Exercise is considered to be the best approach to improve quality of life, and together with a
healthy and adequate dietary pattern, exercise represents the best strategy to reduce the …

Objective Osteoarthritis (OA) appears to be associated with various metabolic disorders, but
the potential contribution of amino acid metabolism to OA pathogenesis has not been clearly …

Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic
factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or …

Despite the success of immunotherapies in adult solid cancers and pediatric hematological
malignancies, limited progress has been made towards implementing these strategies in …

Abstract Introduction Pegargiminase (ADI-PEG 20; ADI) degrades arginine and potentiates
pemetrexed (Pem) cytotoxicity in argininosuccinate synthetase 1 (ASS1)–deficient malignant …

Tuberculosis (TB) and HIV co-infection claims many lives every year. This study assessed
immune responses in Mycobacterium tuberculosis–infected lymph node tissues from HIV …

Helminths are ubiquitous and have chronically infected vertebrates throughout their
evolution. As such helminths have likely exerted considerable selection pressure on our …