A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
Chemotherapy and molecularly targeted approaches represent two very different modes of
cancer treatment and each is associated with unique benefits and limitations. Both types of …
cancer treatment and each is associated with unique benefits and limitations. Both types of …
[HTML][HTML] The utility of exercise testing in patients with lung cancer
D Ha, PJ Mazzone, AL Ries, A Malhotra… - Journal of Thoracic …, 2016 - Elsevier
The harm associated with lung cancer treatment include perioperative morbidity and
mortality and therapy-induced toxicities in various organs, including the heart and lungs …
mortality and therapy-induced toxicities in various organs, including the heart and lungs …
Randomized phase III trial of erlotinib versus docetaxel as second-or third-line therapy in patients with advanced non–small-cell lung cancer: Docetaxel and Erlotinib …
T Kawaguchi, M Ando, K Asami, Y Okano… - Journal of clinical …, 2014 - ascopubs.org
Purpose To investigate the efficacy of erlotinib versus docetaxel in previously treated
patients with advanced non–small-cell lung cancer (NSCLC) in an epidermal growth factor …
patients with advanced non–small-cell lung cancer (NSCLC) in an epidermal growth factor …
[HTML][HTML] Treatment of advanced non small cell lung cancer
MA Bareschino, C Schettino, A Rossi… - Journal of thoracic …, 2011 - ncbi.nlm.nih.gov
Lung cancer is the major cause of cancer death in the world. Non Small Cell Lung Cancer
(NSCLC) accounts approximately 80-85% of all lung cancer diagnosis; the majority of …
(NSCLC) accounts approximately 80-85% of all lung cancer diagnosis; the majority of …
Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
KR Doherty, RL Wappel, DR Talbert, PB Trusk… - Toxicology and applied …, 2013 - Elsevier
Tyrosine kinase inhibitors (TKi) have greatly improved the treatment and prognosis of
multiple cancer types. However, unexpected cardiotoxicity has arisen in a subset of patients …
multiple cancer types. However, unexpected cardiotoxicity has arisen in a subset of patients …
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
Erlotinib-based EGFR targeted therapy has proven significant clinical improvement against
non-small cell lung cancer (NSCLC). However, the anticancer activity of Erlotinib (Ertb) is …
non-small cell lung cancer (NSCLC). However, the anticancer activity of Erlotinib (Ertb) is …
[HTML][HTML] Predictable modulation of cancer treatment outcomes by the gut microbiota
The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we
investigated the contribution of the intestinal microbiome on treatment outcomes in a …
investigated the contribution of the intestinal microbiome on treatment outcomes in a …
[HTML][HTML] Suppression of EGFR/PKC-δ/NF-κB signaling associated with imipramine-inhibited progression of non-small cell lung cancer
PF Yueh, YH Lee, IT Chiang, WT Chen, KL Lan… - Frontiers in …, 2021 - frontiersin.org
Background Anti-depressants have been reported to own anti-tumor potential types of
cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not …
cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not …
Anticancer potential of thiazole derivatives: a retrospective review
S Jain, S Pattnaik, K Pathak, S Kumar… - Mini reviews in …, 2018 - ingentaconnect.com
This review brings forth the potential of thiazole derivatives for their anticancer activities. The
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
[HTML][HTML] Overview on therapeutic options in uncommon EGFR mutant non-small cell lung cancer (NSCLC): new lights for an unmet medical need
G Pretelli, CC Spagnolo, G Ciappina… - International Journal of …, 2023 - mdpi.com
The majority of epidermal growth factor receptor (EGFR) mutations (85–90%) are exon 19
deletions and L858R point mutations of exon 21, characterized by high sensitivity to EGFR …
deletions and L858R point mutations of exon 21, characterized by high sensitivity to EGFR …