[HTML][HTML] Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

L Li, C Acioglu, RF Heary, S Elkabes - Brain, behavior, and immunity, 2021 - Elsevier
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

[HTML][HTML] Promoting tissue regeneration by modulating the immune system

Z Julier, AJ Park, PS Briquez, MM Martino - Acta biomaterialia, 2017 - Elsevier
The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals

MK Vidya, VG Kumar, V Sejian, M Bagath… - International reviews …, 2018 - Taylor & Francis
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …

[HTML][HTML] Heat shock proteins as immunomodulants

T Zininga, L Ramatsui, A Shonhai - Molecules, 2018 - mdpi.com
Heat shock proteins (Hsps) are conserved molecules whose main role is to facilitate folding
of other proteins. Most Hsps are generally stress-inducible as they play a particularly …

Fever and the thermal regulation of immunity: the immune system feels the heat

SS Evans, EA Repasky, DT Fisher - Nature Reviews Immunology, 2015 - nature.com
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Role of the immune system in hypertension

B Rodriguez-Iturbe, H Pons… - Physiological …, 2017 - journals.physiology.org
High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Inflammation and the pathogenesis of atrial fibrillation

YF Hu, YJ Chen, YJ Lin, SA Chen - Nature Reviews Cardiology, 2015 - nature.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of
preventative therapies for AF has been disappointing. The infiltration of immune cells and …

[HTML][HTML] HSP70 multi-functionality in cancer

Z Albakova, GA Armeev, LM Kanevskiy, EI Kovalenko… - Cells, 2020 - mdpi.com
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

The role of toll‐like receptor 4 in infectious and noninfectious inflammation

M Molteni, S Gemma, C Rossetti - Mediators of inflammation, 2016 - Wiley Online Library
Toll‐like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
They are highly conserved receptors that recognize conserved pathogen‐associated …