Angiotensin converting enzyme (ACE) inhibitors which have active moieties excreted mainly
in urine require adjustment of either the dose or the interval between doses in patients with …

BACKGROUND In the Survival and Ventricular Enlargement (SAVE) trial, recurrent
myocardial infarction (MI) was the most important predictor of a poor outcome and conferred …

Major components of the renin-angiotensin system have been localized to cardiac tissue.
Cardiac-derived angiotensin II may benefit myocardial contractility but may promote …

Synopsis Captopril is an angiotensin converting enzyme (ACE) inhibitor which has been
used extensively in the treatment of patients with hypertension and congestive heart failure …

Apart from increasing myocardial oxygen demand, myocardial ischemia may be precipitated
by decreases in coronary blood flow. Alteration in coronary vasomotor tone that affects …

In many instances, the perception of pain is disproportionate to the strength of the algesic
stimulus. Excessive or inadequate pain sensation is frequently observed in cardiovascular …

We investigated whether captopril is able to potentiate vasodilation and prevent tolerance to
a 48-hour infusion of nitroglycerin (NTG). Twenty-six patients were randomly assigned to a 7 …

OBJECTIVES This study was designed to analyze the effects of acute angiotensin-
converting enzyme (ACE) inhibition on myocardial blood flow (MBF) in control and ischemic …

The renin-angiotensin-aldosterone system is a remarkably complex homoeostatic neuroen-
docrine entity. It is an endocrine system regu-lating vascular tone and salt and water …

Angiotensin II is a potent vasoconstrictor of both coronary and peripheral vasculature; it
increases myocardial contractility, promotes myocardial hypertrophy, and possibly con …