The haemoflagellate protozoan Trypanosoma cruzi (T. cruzi) is the causative agent of
Chagas disease (CD), a potentially life-threatening disease. Little by little, remarkable …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Chagas disease and leishmaniasis are neglected tropical diseases caused by the
protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among …

The effect of weak intermolecular interactions on the binding affinity between ligand-protein
complexes plays an important role in stabilizing a ligand at the interface of a protein …

Imidazole remains a privileged heterocycle in drug discovery. Imidazole scaffold is a
ubiquitous motif that is present in several pharmacologically important drug molecules such …

Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a
resurgence in recent years. Here we review the current status of monocyclic and bicyclic …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Abstract Chagas disease and Human African trypanosomiasis (HAT) are caused by
Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while …

In the recent decades, N-heterocycles are widely used as versatile scaffolds for the
development of biologically active compounds and considered as one of the privileged …

Phthalazine derivatives have recently received a lot of interest in the realm of physiologically
active chemical research. Introduce this phthalazine moiety to a researcher in a new …