The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …

The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

MicroRNAs (miRNAs) constitute a novel, phylogenetically extensive family of small RNAs (∼
22 nucleotides) with potential roles in gene regulation. Apart from the finding that miRNAs …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

FoxO (forkhead box O; forkhead members of the O class) are transcription factors that
function under the control of insulin/insulin-like signalling. FoxO factors have been …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

The association of genes with the nuclear pore complex (NPC) and nuclear transport factors
has been implicated in transcriptional regulation. We therefore examined the association of …

In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and
protein synthesis in the cytoplasm poses the requirement of transporting thousands of …

The notion of a “plurifunctional” nucleolus is now well established. However, molecular
mechanisms underlying the biological processes occurring within this nuclear domain …