Impacts of bioinformatics to medicinal chemistry

KC Chou - Medicinal chemistry, 2015 - ingentaconnect.com
Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …

Some remarks on predicting multi-label attributes in molecular biosystems

KC Chou - Molecular Biosystems, 2013 - pubs.rsc.org
Many molecular biosystems and biomedical systems belong to the multi-label systems in
which each of their constituent molecules possesses one or more than one function or …

[HTML][HTML] iACP: a sequence-based tool for identifying anticancer peptides

W Chen, H Ding, P Feng, H Lin, KC Chou - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …

iAMP-2L: a two-level multi-label classifier for identifying antimicrobial peptides and their functional types

X Xiao, P Wang, WZ Lin, JH Jia, KC Chou - Analytical biochemistry, 2013 - Elsevier
Antimicrobial peptides (AMPs), also called host defense peptides, are an evolutionarily
conserved component of the innate immune response and are found among all classes of …

iLoc-lncRNA: predict the subcellular location of lncRNAs by incorporating octamer composition into general PseKNC

ZD Su, Y Huang, ZY Zhang, YW Zhao, D Wang… - …, 2018 - academic.oup.com
Abstract Motivation Long non-coding RNAs (lncRNAs) are a class of RNA molecules with
more than 200 nucleotides. They have important functions in cell development and …

Promises and challenges of big data computing in health sciences

T Huang, L Lan, X Fang, P An, J Min, F Wang - Big Data Research, 2015 - Elsevier
With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …

iHSP-PseRAAAC: Identifying the heat shock protein families using pseudo reduced amino acid alphabet composition

PM Feng, W Chen, H Lin, KC Chou - Analytical biochemistry, 2013 - Elsevier
Heat shock proteins (HSPs) are a type of functionally related proteins present in all living
organisms, both prokaryotes and eukaryotes. They play essential roles in protein–protein …

[HTML][HTML] The emerging importance role of m6A modification in liver disease

S Wang, S Gao, W Ye, Y Li, J Luan, X Lv - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) modification, as one of the most common types of inner
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …

[HTML][HTML] iRSpot-TNCPseAAC: identify recombination spots with trinucleotide composition and pseudo amino acid components

WR Qiu, X Xiao, KC Chou - International journal of molecular sciences, 2014 - mdpi.com
Meiosis and recombination are the two opposite aspects that coexist in a DNA system. As a
driving force for evolution by generating natural genetic variations, meiotic recombination …

Ictx‐type: a sequence‐based predictor for identifying the types of conotoxins in targeting ion channels

H Ding, EZ Deng, LF Yuan, L Liu, H Lin… - BioMed research …, 2014 - Wiley Online Library
Conotoxins are small disulfide‐rich neurotoxic peptides, which can bind to ion channels with
very high specificity and modulate their activities. Over the last few decades, conotoxins …