Impacts of bioinformatics to medicinal chemistry
KC Chou - Medicinal chemistry, 2015 - ingentaconnect.com
Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
Some remarks on predicting multi-label attributes in molecular biosystems
KC Chou - Molecular Biosystems, 2013 - pubs.rsc.org
Many molecular biosystems and biomedical systems belong to the multi-label systems in
which each of their constituent molecules possesses one or more than one function or …
which each of their constituent molecules possesses one or more than one function or …
[HTML][HTML] iACP: a sequence-based tool for identifying anticancer peptides
Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …
expensive and have some deleterious side effects on normal cells. Fortunately, the …
iAMP-2L: a two-level multi-label classifier for identifying antimicrobial peptides and their functional types
Antimicrobial peptides (AMPs), also called host defense peptides, are an evolutionarily
conserved component of the innate immune response and are found among all classes of …
conserved component of the innate immune response and are found among all classes of …
iLoc-lncRNA: predict the subcellular location of lncRNAs by incorporating octamer composition into general PseKNC
Abstract Motivation Long non-coding RNAs (lncRNAs) are a class of RNA molecules with
more than 200 nucleotides. They have important functions in cell development and …
more than 200 nucleotides. They have important functions in cell development and …
Promises and challenges of big data computing in health sciences
With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …
data can be collected from various sources and can be analyzed in an unprecedented way …
iHSP-PseRAAAC: Identifying the heat shock protein families using pseudo reduced amino acid alphabet composition
Heat shock proteins (HSPs) are a type of functionally related proteins present in all living
organisms, both prokaryotes and eukaryotes. They play essential roles in protein–protein …
organisms, both prokaryotes and eukaryotes. They play essential roles in protein–protein …
[HTML][HTML] The emerging importance role of m6A modification in liver disease
S Wang, S Gao, W Ye, Y Li, J Luan, X Lv - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) modification, as one of the most common types of inner
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …
[HTML][HTML] iRSpot-TNCPseAAC: identify recombination spots with trinucleotide composition and pseudo amino acid components
WR Qiu, X Xiao, KC Chou - International journal of molecular sciences, 2014 - mdpi.com
Meiosis and recombination are the two opposite aspects that coexist in a DNA system. As a
driving force for evolution by generating natural genetic variations, meiotic recombination …
driving force for evolution by generating natural genetic variations, meiotic recombination …
Ictx‐type: a sequence‐based predictor for identifying the types of conotoxins in targeting ion channels
Conotoxins are small disulfide‐rich neurotoxic peptides, which can bind to ion channels with
very high specificity and modulate their activities. Over the last few decades, conotoxins …
very high specificity and modulate their activities. Over the last few decades, conotoxins …