SARS-CoV-2 variants, vaccines, and host immunity

P Mistry, F Barmania, J Mellet, K Peta… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus
that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes …

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency

SC Kim, SS Sekhon, WR Shin, G Ahn, BK Cho… - Molecular & cellular …, 2022 - Springer
Background mRNA vaccines hold great potential as therapeutic techniques against viral
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …

Lipid-based nanoparticles for delivery of vaccine adjuvants and antigens: toward multicomponent vaccines

D Chatzikleanthous, DT O'Hagan… - Molecular …, 2021 - ACS Publications
Despite the many advances that have occurred in the field of vaccine adjuvants, there are
still unmet needs that may enable the development of vaccines suitable for more …

[HTML][HTML] Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

S Seneff, G Nigh, AM Kyriakopoulos… - Food and Chemical …, 2022 - Elsevier
Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …

The genetic and biochemical determinants of mRNA degradation rates in mammals

V Agarwal, DR Kelley - Genome biology, 2022 - Springer
Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors
governing it remain poorly characterized. Understanding the genetic and biochemical …

Modulating epigenetic modifications for cancer therapy

LJ Castro-Muñoz, EV Ulloa, C Sahlgren… - Oncology …, 2023 - spandidos-publications.com
Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Advances in soft mist inhalers

V Komalla, CYJ Wong, I Sibum… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …

COVID‐19 in early 2023: Structure, replication mechanism, variants of SARS‐CoV‐2, diagnostic tests, and vaccine & drug development studies

I Polatoğlu, T Oncu‐Oner, I Dalman, S Ozdogan - MedComm, 2023 - Wiley Online Library
Abstract Coronavirus Disease‐19 (COVID‐19) is an infectious disease caused by severe
acute respiratory syndrome‐coronaviruses‐2 (SARS‐CoV‐2), a highly pathogenic and …

Administration of COVID-19 vaccines in immunocompromised patients

M Negahdaripour, M Shafiekhani, SMI Moezzi… - International …, 2021 - Elsevier
Since the beginning of vaccination programs against COVID-19 in different countries,
several populations such as patients with specific immunological conditions have been …

Preventing the next pandemic: is live vaccine efficacious against monkeypox, or is there a need for killed virus and mRNA vaccines?

A Abdelaal, A Reda, BI Lashin, BE Katamesh… - Vaccines, 2022 - mdpi.com
(1) Background: The monkeypox virus (MPV) is a double-stranded DNA virus belonging to
the Poxviridae family, Chordopoxvirinae subfamily, and Orthopoxvirus genus. It was called …