Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in
diverse biological processes like growth, differentiation, metabolism and apoptosis in …

Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling
processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine …

Learning and memory arise through activity-dependent modifications of neural circuits.
Although the activity dependence of synaptic efficacy has been studied extensively, less is …

Chemical probes for interrogating biological processes are of considerable current interest.
Cell permeable small molecule tools have a major role in facilitating the functional …

Numerous Knoevenagel condensations of solid or liquid aromatic aldehydes are performed
with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and …

The effect of the isoflavones, genistein, daidzein, and biochanin A on the growth of the
LNCaP and DU‐145 human prostate cancer cell lines has been examined. Genistein and …

With the manufacture of imatinib, researchers introduced tyrosine kinase inhibitors (TKIs)
into the clinical setting in 2000 to treat cancers; approximately fifteen other TKIs soon …