For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial
extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard …

To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

We report orthotopic (life‐supporting) survival of genetically engineered porcine cardiac
xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work …

Objective Genetically engineered pigs are thought to be an alternative organ source for
patients in end-stage heart failure unable to receive a timely allograft. However, cardiac …

Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients
whose β-cell functions have been abolished. However, the lack of donor organs has been …

Progress in pig organ xenotransplantation has been made largely through (1) genetic
engineering of the organ-source pig to protect its tissues from the human innate immune …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

Abstract Purpose of Review The first successful pig to human cardiac xenotransplantation in
January 2022 represented a major step forward in the fields of heart failure, immunology …

A summary of the scientific rationale of the advancements that led to the first genetically
modified pig-to-human cardiac xenotransplantation is lacking in a complex and rapidly …