Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …

After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have
gained a detailed knowledge of the cells involved, specific recognition mechanisms and …

B cells are capable of a wide range of effector functions including antibody secretion,
antigen presentation, cytokine production, and generation of immunological memory. A …

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …

FAS belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that
contains an intracellular" death domain" and triggers apoptosis. Its physiological ligand …

Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic
cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors …

The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …

Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor
receptor superfamily that contain an intracellular death domain, can initiate apoptosis …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …