Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

More than 95 percent of infants who have neonatal stroke survive to adulthood, and many
have residual motor or cognitive disabilities. This article makes the point that recognition of …

Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Perinatal hypoxic‐ischemic encephalopathy (HIE) is an important cause of brain injury in the
newborn and can result in long‐term devastating consequences. Perinatal hypoxia is a vital …

The immature brain has long been considered to be resistant to the damaging effects of
hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific …

Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although
systemic and cerebrovascular physiologic factors play an important role in the initial phases …

Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and
associated disabilities in children. Cerebral palsy is one of the most costly neurologic …

Programmed cell death (apoptosis) is a normal process in the developing nervous system.
Recent data suggest that certain features seen in the process of programmed cell death may …