[HTML][HTML] Microenvironment-Responsive Nanosystems for Osteoarthritis Therapy

S Li, Y Xiong, H Zhu, T Ma, X Sun, J Xiao - Engineered Regeneration, 2023 - Elsevier
Osteoarthritis (OA) represents an enduring and widespread global burden, causing
significant morbidity and disability, whose pathology is characterized by persistent …

Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

M Wu, C Hong, C Shen, D Xie, T Chen, A Wu, Q Li - Drug Delivery, 2023 - Taylor & Francis
The conventional treatment methods used for the management of autoimmune diseases
(ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of …

Mitochondrial-targeting and NIR-responsive Mn3O4@ PDA@ Pd-SS31 nanozymes reduce oxidative stress and reverse mitochondrial dysfunction to alleviate …

Y Li, J Yang, X Chen, H Hu, N Lan, J Zhao, L Zheng - Biomaterials, 2024 - Elsevier
Mitochondrial reactive oxygen species (mROS) play a crucial role in the process of
osteoarthritis (OA), which may be a promising target for therapy of OA. In this study, novel …

Curcumin-loaded mesoporous polydopamine nanoparticles modified by quaternized chitosan against bacterial infection through synergistic effect

X Han, W Gao, Z Zhou, Y Li, D Sun, H Gong… - International Journal of …, 2024 - Elsevier
Clinically, open wounds caused by accidental trauma and surgical lesion resection are
easily infected by external bacteria, hindering wound healing. Antibacterial photodynamic …

[HTML][HTML] Synergistic chemotherapy/PTT/oxygen enrichment by multifunctional liposomal polydopamine nanoparticles for rheumatoid arthritis treatment

X Fu, Y Song, X Feng, Z Liu, W Gao, H Song… - Asian Journal of …, 2024 - Elsevier
Amultifunctional liposomal polydopamine nanoparticle (MPM@ Lipo) was designed in this
study, to combine chemotherapy, photothermal therapy (PTT) and oxygen enrichment to …

Biocompatible copper formate-based nanoparticles with strong antibacterial properties for wound healing

Y Zhou, P Sun, Y Cao, J Yang, Q Wu, J Peng - Journal of …, 2023 - Springer
Copper-based antibacterial materials have emerged as a potential alternative for combating
bacterial infections, which continue to pose significant health risks. Nevertheless, the use of …

[HTML][HTML] Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways

T Cui, Y Lan, Y Lu, F Yu, S Lin, Y Fu, J Qiu… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there is
currently no effective treatment. Isoorientin (ISO) is a natural plant extract that has …

Microneedle‐Delivered PDA@ Exo for Multifaceted Osteoarthritis Treatment via PI3K‐Akt‐mTOR Pathway

Z Li, H Lu, L Fan, X Ma, Z Duan, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Osteoarthritis (OA) is marked by cartilage deterioration, subchondral bone changes, and an
inflammatory microenvironment. The study introduces the Microneedle‐Delivered …

Holmium (III)-doped multifunctional nanotheranostic agent for ultra-high-field magnetic resonance imaging-guided chemo-photothermal tumor therapy

R Zhang, M Liu, S Liu, X Liang, R Lu, X Shuai, D Wu… - Acta Biomaterialia, 2023 - Elsevier
Abstract Ultra-high-field (UHF) MRI has shown great advantages over low-field magnetic
resonance imaging (MRI). Despite being the most commonly used MRI contrast agents …

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

MM Chen, Y Li, Y Zhu, WC Geng, FY Chen, JJ Li… - ACS …, 2024 - ACS Publications
The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in
therapeutic paradigms from monotherapy to combination therapy, which could augment …