Gastro-oesophageal reflux disease (GERD) is a common disorder in adults and children.
The global prevalence of GERD is high and increasing. Non-erosive reflux disease is the …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

Keywords: FUNCTIONAL DISEASES OF THE DIGESTIVE SYSTEM, FUNCTIONAL
HEARTBURN, FUNCTIONAL DYSPEPSIA, BILIARY DYSFUNCTION, IRRITABLE BOWEL …

Best Practice Advice 1 A diagnosis of functional heartburn should be considered when
retrosternal burning pain or discomfort persists despite maximal (double-dose) proton pump …

Patients with esophageal symptoms potentially associated with gastroesophageal reflux
disease such as heartburn, regurgitation, chest pain, or cough represent one of the most …

The focus on a symptom-based definition for gastroesophageal reflux disease (GERD) in
adults and children has contributed to widespread use of acid suppression medications in …

Background When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies
functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom …

The better ability to interpret impedance-pH tracings together with earlier data on the
different prevalence of microscopic esophagitis in RH and FH patients, and recent studies …

Methods Over a 5-year period, children with negative upper endoscopy, who underwent
esophageal pH-impedance (off-therapy) for persisting symptoms not responsive to proton …

Gastroesophageal reflux (GOR) is defined as “the passage of gastric contents into the
esophagus with or without regurgitation and vomiting” and gastroesophageal reflux disease …