Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Ferroptosis, a novel form of regulated cell death induced by iron-dependent lipid
peroxidation, plays an essential role in the development and drug resistance of tumors …

The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of
breast cancer tumors. However, the underlying mechanism is not fully understood. Here …

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of
the prominent roles is to regulate gene expression. A vast number of circular RNAs …

Although more than 98% of the human genome is non-coding, nearly all of the drugs on the
market target one of about 700 disease-related proteins. The historical reluctance to invest …

Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in
cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for …

Background The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has
been reported to be overexpressed in colorectal cancer (CRC). However, its underlying …