Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

WH Tham, J Healer, AF Cowman - Trends in parasitology, 2012 - cell.com
The global agenda for malaria eradication would benefit from development of a highly
efficacious vaccine that protects against disease and interrupts transmission of Plasmodium …

Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparum invasion of erythrocytes

JC Volz, A Yap, X Sisquella, JK Thompson, NTY Lim… - Cell host & …, 2016 - cell.com
Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and
cause malaria. Invasion requires multiple interactions between merozoite ligands and …

Molecular interactions and signaling mechanisms during erythrocyte invasion by malaria parasites

D Gaur, CE Chitnis - Current opinion in microbiology, 2011 - Elsevier
Invasion of erythrocytes by Plasmodium merozoites is a complex process that is mediated by
specific molecular interactions. Here, we review recent studies on interactions between …

[HTML][HTML] Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker …

JS Richards, TU Arumugam, L Reiling… - The Journal of …, 2013 - journals.aai.org
The development of effective malaria vaccines and immune biomarkers of malaria is a high
priority for malaria control and elimination. Ags expressed by merozoites of Plasmodium …

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

AD Douglas, AR Williams, JJ Illingworth… - Nature …, 2011 - nature.com
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are
mostly focused on well-studied merozoite antigens that induce immune responses after …

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

WH Tham, DW Wilson, S Lopaticki… - Proceedings of the …, 2010 - National Acad Sciences
Plasmodium falciparum is responsible for the most severe form of malaria disease in
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite …

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

L Chen, S Lopaticki, DT Riglar, C Dekiwadia… - PLoS …, 2011 - journals.plos.org
Invasion of erythrocytes by Plasmodium falciparum involves a complex cascade of protein-
protein interactions between parasite ligands and host receptors. The reticulocyte binding …

Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites

S Lopaticki, AG Maier, J Thompson… - Infection and …, 2011 - Am Soc Microbiol
Plasmodium falciparum causes the most severe form of malaria in humans and invades
erythrocytes using multiple ligand-receptor interactions. Two important protein families …

Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

AR Williams, AD Douglas, K Miura, JJ Illingworth… - PLoS …, 2012 - journals.plos.org
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum,
which cause the symptoms and severe manifestations of malaria. We recently found that …

Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum

C Spadafora, GA Awandare, KM Kopydlowski… - PLoS …, 2010 - journals.plos.org
Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its
life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular …