Innovations in genomics and big data analytics for personalized medicine and health care: A review
Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …
based studies to large-scale, data-driven research. As big data is dependent on the …
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
A biobank of small cell lung cancer CDX models elucidates inter-and intratumoral phenotypic heterogeneity
KL Simpson, R Stoney, KK Frese, N Simms, W Rowe… - Nature Cancer, 2020 - nature.com
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …
[HTML][HTML] Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes
W Zhang, L Girard, YA Zhang, T Haruki… - … lung cancer research, 2018 - ncbi.nlm.nih.gov
Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
Epithelial-mesenchymal heterogeneity implies that cells within the same tumor can exhibit
different phenotypes—epithelial, mesenchymal, or one or more hybrid epithelial …
different phenotypes—epithelial, mesenchymal, or one or more hybrid epithelial …
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
Adopting a systems approach, we devise a general workflow to define actionable subtypes
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
Phenotypic plasticity, bet-hedging, and androgen independence in prostate cancer: role of non-genetic heterogeneity
MK Jolly, P Kulkarni, K Weninger, J Orban… - Frontiers in …, 2018 - frontiersin.org
It is well known that genetic mutations can drive drug resistance and lead to tumor relapse.
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …
Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools
Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …
Parity and time reversal elucidate both decision-making in empirical models and attractor scaling in critical Boolean networks
We present new applications of parity inversion and time reversal to the emergence of
complex behavior from simple dynamical rules in stochastic discrete models. Our parity …
complex behavior from simple dynamical rules in stochastic discrete models. Our parity …