All mammalian eggs are surrounded by a relatively thick extracellular coat, the zona
pellucida, that plays vital roles during oogenesis, fertilization, and preimplantation …

The zona pellucida (ZP) is an extracellular matrix that surrounds all mammalian oocytes,
eggs, and early embryos and plays vital roles during oogenesis, fertilization, and …

Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma
membrane of mammalian eggs. Its presence is essential for successful completion of …

Receptor tyrosine kinases (RTKs) are proteins that upon ligand stimulation undergo
dimerization and autophosphorylation. Eph receptors (EphRs) are RTKs that are found in …

Acrosome reaction is crucial to the penetration of spermatozoa through the zona pellucida
(ZP). Glycosylation of ZP glycoproteins is important in spermatozoa-ZP interaction. Human …

Amyloids are traditionally considered pathological protein aggregates that play causative
roles in neurodegenerative disease, diabetes and prionopathies. However, increasing …

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …

The terminal differentiation of epithelial cells involves changes in the apical compartment,
including remodeling of the cytoskeleton and junctions to modify its three-dimensional …