The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

Currently, immunotherapy targeting programmed cell death 1 (PD-1) or programmed death
ligand 1 (PD-L1) has revolutionized the treatment strategy of human cancer patients …

The percentage of low response and adaptive resistance to current antibody‐based immune
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …

Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for
maintaining immunological balance and are a significant component of the …

Objective The immune microenvironment of HPV‐associated (HPV+) oropharyngeal
squamous cell carcinomas (OPSCCs)(HPV+ OPSCCs) differs from that of HPV‐independent …

Accumulating evidence indicates that aberrant signalling stemming from genetic
abnormalities in cancer cells has a fundamental role in their evasion of antitumour immunity …

Extracellular vesicle (EV) secretion is a dynamic process crucial to cellular communication.
Temporally sorting EVs, ie, separating the newly-produced ones from the pre-existing, can …

The lack of comprehensive diagnostics and consensus analytical models for evaluating the
status of a patient's immune system has hindered a wider adoption of immunoprofiling for …

VISTA (V-domain Ig suppressor of T cell activation) is a novel immune checkpoint protein
and represents a promising target for cancer immunotherapy. Here, we report the design …

Early in solid tumor development, antigens are presented in tumor-draining lymph nodes
(tdLNs), a process that is necessary to set up immune surveillance. Recent evidence …