The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …
role in regulating immune responses provided a deeper understanding of self-tolerance …
[HTML][HTML] The therapeutic potential of PD-1/PD-L1 pathway on immune-related diseases: based on the innate and adaptive immune components
P Zhang, Y Wang, Q Miao, Y Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Currently, immunotherapy targeting programmed cell death 1 (PD-1) or programmed death
ligand 1 (PD-L1) has revolutionized the treatment strategy of human cancer patients …
ligand 1 (PD-L1) has revolutionized the treatment strategy of human cancer patients …
Aptamer‐Assisted Blockade of the Immune Suppressor Sialic Acid‐Binding Immunoglobulin‐Like Lectin‐15 for Cancer Immunotherapy
Q Wu, X Wei, F Chen, M Huang… - Angewandte Chemie …, 2023 - Wiley Online Library
The percentage of low response and adaptive resistance to current antibody‐based immune
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …
Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review
Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for
maintaining immunological balance and are a significant component of the …
maintaining immunological balance and are a significant component of the …
Prognostic Significance of the Microenvironment in Human Papillomavirus Oropharyngeal Carcinoma: A Systematic Review
R Baudouin, S Hans, Q Lisan, B Morin… - The …, 2024 - Wiley Online Library
Objective The immune microenvironment of HPV‐associated (HPV+) oropharyngeal
squamous cell carcinomas (OPSCCs)(HPV+ OPSCCs) differs from that of HPV‐independent …
squamous cell carcinomas (OPSCCs)(HPV+ OPSCCs) differs from that of HPV‐independent …
Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine
S Kumagai, K Itahashi, H Nishikawa - Nature Reviews Clinical …, 2024 - nature.com
Accumulating evidence indicates that aberrant signalling stemming from genetic
abnormalities in cancer cells has a fundamental role in their evasion of antitumour immunity …
abnormalities in cancer cells has a fundamental role in their evasion of antitumour immunity …
Capturing nascent extracellular vesicles by metabolic glycan labeling-assisted microfluidics
Q Wu, W Wang, C Zhang, Z You, Y Zeng, Y Lu… - Nature …, 2023 - nature.com
Extracellular vesicle (EV) secretion is a dynamic process crucial to cellular communication.
Temporally sorting EVs, ie, separating the newly-produced ones from the pre-existing, can …
Temporally sorting EVs, ie, separating the newly-produced ones from the pre-existing, can …
Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer
D Dyikanov, A Zaitsev, T Vasileva, I Wang, AA Sokolov… - Cancer Cell, 2024 - cell.com
The lack of comprehensive diagnostics and consensus analytical models for evaluating the
status of a patient's immune system has hindered a wider adoption of immunoprofiling for …
status of a patient's immune system has hindered a wider adoption of immunoprofiling for …
Design, Synthesis, and Antitumor Activity Evaluation of Novel VISTA Small Molecule Inhibitors
C Sun, Y He, G Wang, G Zhang, Y Zhang… - Journal of Medicinal …, 2024 - ACS Publications
VISTA (V-domain Ig suppressor of T cell activation) is a novel immune checkpoint protein
and represents a promising target for cancer immunotherapy. Here, we report the design …
and represents a promising target for cancer immunotherapy. Here, we report the design …
[HTML][HTML] The tumor-draining lymph node as a reservoir for systemic immune surveillance
Early in solid tumor development, antigens are presented in tumor-draining lymph nodes
(tdLNs), a process that is necessary to set up immune surveillance. Recent evidence …
(tdLNs), a process that is necessary to set up immune surveillance. Recent evidence …