Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat …

Background Myocardial infarction (MI) is a severe disease that often associated with
dysfunction of angiogenesis. Cell-based therapies for MI using mesenchymal stem cell …

Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …

The cardiac benefits of exercise have been recognized for centuries. Studies have
undisputedly shown that regular exercise is beneficial for the cardiovascular system in …

Sepsis is a common and life-threatening systemic disorder, often leading to acute injury of
multiple organs. Here, we show that remote ischemic preconditioning (rIPC), elicited by brief …

Abstract Cardiovascular (CV) disease (CVD) remains the leading cause of major morbidity
and CVD-and all-cause mortality in most of the world. It is now clear that regular physical …

Myocardial infarction (MI) is a fatal heart disease that affects millions of lives worldwide each
year. This study investigated the roles of HIF-1α/lncRNA-TUG1 in mitochondrial dysfunction …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …