The upper gastrointestinal (GI) cancers have various carcinogenic pathways and precursor
lesions, such as dysplasia for esophageal squamous cell carcinoma, Barrett esophagus for …

Patients with Barrett's esophagus (BE) are at increased risk of developing esophageal
adenocarcinoma (EAC). Clinical neoplastic progression risk factors, such as age and the …

In the natural history of Helicobacter pylori-related gastric carcinogenesis, H pylori chronic
active gastritis progresses to gastric atrophy and intestinal metaplasia (IM), which represent …

To explore the role of aberrant hypermethylation of cancer-related genes, such as P16,
MGMT, and hMLH1, in the esophageal squamous cell carcinoma (ESCC) as well as its …

The role of promoter methylation in the process of cancer cell metastasis has not yet been
studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal …

Several studies have found that the promoter CpG island is frequently methylated in gastric
cancer. The CpG island methylator phenotype (CIMP) defines concordant methylation of …

Background TMEFF2 is a protein containing a single EGF-like domain and two follistatin-like
modules. The biological function of TMEFF2 remains unclear with conflicting reports …

Background: Epstein–Barr virus (EBV)-associated gastric carcinomas (GC) constitute a
distinct clinicopathological entity of gastric cancer. In order to determine underlying distinct …

Simple Summary We recently came across an intriguing protein while screening for tumour-
specific apoptosis inducers. It is known as the transmembrane protein with an EGF-like and …

Background Despite the efforts to describe the molecular landscape of esophageal
adenocarcinoma (EAC) and its precursor lesion Barrett's esophagus (BE), discrepant …