Seven pillars of small airways disease in asthma and COPD: supporting opportunities for novel therapies
Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …
the importance of the small airways and their contribution to symptoms. Indeed, significant …
Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …
PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021 - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …
terminal airway morphology rapidly and safely, providing novel information not possible …
[HTML][HTML] How high resolution 3-dimensional imaging changes our understanding of postnatal lung development
JC Schittny - histochemistry and cell biology, 2018 - Springer
During the last 10+ years biologically and clinically significant questions about postnatal
lung development could be answered due to the application of modern cutting-edge …
lung development could be answered due to the application of modern cutting-edge …
Feasibility, tolerability and safety of pediatric hyperpolarized 129Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis
Abstract Background Hyperpolarized 129 Xe is a promising contrast agent for MRI of
pediatric lung function, but its safety and tolerability in children have not been rigorously …
pediatric lung function, but its safety and tolerability in children have not been rigorously …
Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
Emphysema Index Based on Hyperpolarized 3He or 129Xe Diffusion MRI: Performance and Comparison with Quantitative CT and Pulmonary …
Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases
have shown promise in the characterization of emphysema in patients with chronic …
have shown promise in the characterization of emphysema in patients with chronic …
[HTML][HTML] Functional lung imaging using novel and emerging MRI techniques
CT Foo, D Langton, BR Thompson, F Thien - Frontiers in Medicine, 2023 - frontiersin.org
Respiratory diseases are leading causes of death and disability in the world. While early
diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools …
diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools …
Machine learning and CT texture features in ex-smokers with no CT evidence of emphysema and mildly abnormal diffusing capacity
Rationale and Objectives Ex-smokers without spirometry or CT evidence of chronic
obstructive pulmonary disease (COPD) but with mildly abnormal diffusing capacity of the …
obstructive pulmonary disease (COPD) but with mildly abnormal diffusing capacity of the …
Hyperpolarized 129Xe MRI at low field: Current status and future directions
S Perron, A Ouriadov - Journal of Magnetic Resonance, 2023 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) is dictated by the magnetization of the sample,
and is thus a low-sensitivity imaging method. Inhalation of hyperpolarized (HP) noble gases …
and is thus a low-sensitivity imaging method. Inhalation of hyperpolarized (HP) noble gases …
A simplified parametrised model for lung microstructures capable of mimicking realistic geometrical and mechanical properties
The respiratory zone of mammalian lungs contains several millions of so-called alveoli. The
geometrical and mechanical properties of this microstructure are crucial for respiration and …
geometrical and mechanical properties of this microstructure are crucial for respiration and …