[Frontiers in Bioscience 9, 1059-1072, May 1, 2004] 1059 THE SEARCH FOR NEW
STERILIZING ANTI-TUBERCULOSIS DRUGS Denis A. Mitchis Page 1 [Frontiers in Bioscience …

Vitamin D deficiency is associated with susceptibility to tuberculosis, and its biologically
active metabolite, 1α, 25 dihydroxyvitamin D 3 (1α, 25 (OH) 2 D 3), has pleiotropic immune …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents
a major public health threat in many countries. Bioluminescence, the production of light by …

Objectives Tuberculosis drug development is hampered by the slow growth of
Mycobacterium tuberculosis. Bioluminescence, light produced by an enzymatic reaction …

Objectives The intracellularly surviving and slow-growing pathogen, Mycobacterium
tuberculosis, adapts the host cell environment for its active and dormant life cycle. It is …

The antimycobacterial activity of two clinically approved antifungal azole drugs, clotrimazole
and econazole, was evaluated against Mycobacterium tuberculosis H37Rv under in vitro …

The availability of cloned luciferase genes from fireflies (luc) and from bacteria (luxAB) has
led to the widespread use of bioluminescence as a reporter to measure cell viability and …

To understand fully cellular mechanisms during bone tissue repair and engineering, there is
a need to develop reproducible three-dimensional organotypic culture models, whereby …

Objective Immune suppression during critical illness predisposes to serious infections. We
sought to determine the mechanisms regulating tolerance and cross-tolerance to common …

Bacterial peptide deformylase (PDF) catalyses removal of the N-terminal formyl group of
proteins and is essential for protein maturation, growth and survival of bacteria. Thus, PDF …