Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Articular cartilage (AC) sheathes joint surfaces and minimizes friction in diarthrosis. The
resident cell population, chondrocytes, are surrounded by an extracellular matrix and a …

Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in
older populations and is expected to be the most dominant cause of disability in the world …

With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis
(OA), alternatives have been sought. Furthermore, the inability of current medications to …

Osteoarthritis is the most common musculoskeletal progressive disease, with the knee as
the most commonly affected joint in the human body. While several new medications are still …

The knee is the joint most frequently involved in osteoarthritis and represents a significant
contributor to patient morbidity and impaired functional status. Major risk factors include …

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage
degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has …

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

The anterior cruciate ligament (ACL) is one of the main stabilizer parts of the knee. ACL
injury leads to causes of osteoarthritis risk. ACL rupture is common in the young athletic …

One of the practical ways to manage the disease flares of arthritis is using an intra-articular
depot formulation of glucocorticoids. Hydrogels, as controllable drug delivery systems, are …