The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

Mammalian reproductive function includes puberty onset and completion, reproductive
cyclicity, steroidogenesis, gametogenesis, fertilization, pregnancy, and lactation; all are …

The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons.
Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release …

Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and
subsequent luteinizing hormone (LH) release. Estradiol acts via estrogen receptor α (ERα) …

Kisspeptin neurons located in the hypothalamic arcuate nucleus are thought to represent the
GnRH pulse generator responsible for driving pulsatile LH secretion. The recent …

Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting
neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing …

This mini-review summarizes key points from the Clark Sawin Memorial Lecture on the
History of Estrogen delivered at Endo 2018 and focuses on the rationales and motivation …

The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …