During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Abstract Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-
transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …

The immune system regulates angiogenesis in cancer with both pro-and antiangiogenic
activities. The induction of angiogenesis is mediated by tumor-associated macrophages and …

Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …

T-cell–based immunotherapies can be effective in the treatment of large vascularized
tumors, but they rely on adoptive transfer of substantial numbers (∼ 20 million) of tumor …

The angiogenic process involves several cell types and mediators, which interact to
establish a specific microenvironment suitable for the formation of new capillaries from pre …

The role of a tumor immune infiltrate in cancer progression and metastasis has been
debated frequently. Although often considered to be associated with improved prognosis …

Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-
endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 …

Cancer metastasis is the leading cause of high mortality and disease recurrence in breast
cancer. In this study, a novel tumor microenvironment charge reversal polymetformin (PMet) …