Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Accumulating evidence implicates heterogeneity within cancer cell populations in the
response to stressful exposures, including drug treatments. While modeling the acute …

The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on
lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs) …

Melanomas are highly heterogeneous tumors, but the biological significance of their
different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases,, and …