Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

The use of biomarkers in medicine has become essential in clinical practice in order to help
with diagnosis, prognostication and prediction of treatment response. Since Alexander …

Evasion of the immune response is a hallmark of cancer, and programmed cell death 1 (PD-
1) and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3 …

Human Glyco_18 domain-containing proteins constitute a family of chitinases and chitinase-
like proteins. Chitotriosidase and AMCase are true enzymes which hydrolyse chitin and …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

YKL-40, a 40-kDa secreted glycoprotein, with its gene located on chromosome 1q32. 1, is
produced by cancer cells and inflammatory cells and has a role in inflammation, cell …

Purpose An elevated count of blood neutrophils and monocytes recently was shown
independently to predict short survival in patients with stage IV melanoma undergoing …

Biomarkers are tumour-or host-related factors that correlate with tumour biological behaviour
and patient prognosis. High-throughput analytical techniques—DNA and RNA microarrays …

Validated biomarkers for patients suffering from gliomas are urgently needed for
standardizing measurements of the effects of treatment in daily clinical practice and trials …

Chitinase 3-Like-1 (CHI3L1) is a secreted 40 kDa glycoprotein that is upregulated in a
number of human cancers and in non-neoplastic disease states characterized by chronic …