Purpose: As noninvasive biomarkers are an important unmet need for neuroendocrine
neoplasms (NEN), biomarker potential of genome-wide molecular profiling of plasma cell …

Abstract Objective Copy number variations (CNVs) play crucial roles in physiological and
pathological processes, including cancer. However, the functional implications of somatic …

Abstract Background Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor
microenvironment of lung adenocarcinoma (LUAD) and are often associated with poorer …

We investigated the role of TONSL, a mediator of homologous recombination repair (HRR),
in stalled replication fork double-strand breaks (DSBs) in cancer. Publicly available clinical …

Breast cancer is a heterogeneous disease caused by various alterations in the genome or
transcriptome. Molecular subtypes of breast cancer have been reported, but useful …

In cancer, copy number aberrations (CNAs) represent a type of nearly ubiquitous and
frequently extensive structural genome variations. To disentangle the molecular …

Somatic copy number alterations (SCNA) involving either a whole chromosome or just one
of the arms, or even smaller parts, have been described in about 88% of human tumors. This …

The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most
frequent loss-gain co-aneuploidy pair in human cancers, a phenomenon that has been …

The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most
frequent loss–gain co-aneuploidy pair in human cancers. This phenomenon has been …

Cancer is a leading cause of death worldwide, necessitating novel therapies and effective
patient stratification. Copy Number Alterations (CNAs), characterized by chromosomal …