Spermidine, a natural autophagy inducer, has a variety of health effects, such as antitumor,
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …

High incidences of morbidity and mortality associated with age-related diseases among the
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …

Osteoarthritis (OA) is an age-related joint disease in which inflammation and extracellular
matrix (ECM) degradation play a crucial role in the destruction of articular cartilage …

Background Spermidine (SPD) is a natural polyamine that shows beneficial effects on
osteoarthritis (OA). However, the effect of SPD on cartilage inflammation remains unknown …

Cells communication in response to extracellular or biophysical stimulus relies on
elaborated systems of signal transduction. In the course of most signal pathway, the …

Objectives: Osteoarthritis (OA) is a joint disease characterized by degeneration of joint
cartilage and is a significant cause of severe joint pain, physical disability, and impaired …

Osteoarthritis is a chronic degenerative musculoskeletal disease characterized by
pathological changes in joint structures along with the incidence of which increases with …

Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in
the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common …

Spermidine alkaloids are a kind of natural products possessing an aliphatic triamine
structure with three or four methylene groups between two N-atoms. Spermidine alkaloids …