A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and …
D Zou, Z Zhao, L Li, Y Min, D Zhang, A Ji… - … Reviews in Food …, 2022 - Wiley Online Library
Spermidine, a natural autophagy inducer, has a variety of health effects, such as antitumor,
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …
[HTML][HTML] New insights into the roles and mechanisms of spermidine in aging and age-related diseases
YQ Ni, YS Liu - Aging and disease, 2021 - ncbi.nlm.nih.gov
High incidences of morbidity and mortality associated with age-related diseases among the
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …
Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
C Zheng, J Chen, Y Wu, X Wang, Y Lin, L Shu… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …
[HTML][HTML] Secoisolariciresinol diglucoside ameliorates osteoarthritis via nuclear factor-erythroid 2-related factor-2/nuclear factor kappa B Pathway: in vitro and in vivo …
Z Zhang, S Wang, X Liu, Y Yang, Y Zhang, B Li… - Biomedicine & …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease in which inflammation and extracellular
matrix (ECM) degradation play a crucial role in the destruction of articular cartilage …
matrix (ECM) degradation play a crucial role in the destruction of articular cartilage …
BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway
X Mao, B Yan, H Chen, P Lai, J Ma - International Immunopharmacology, 2023 - Elsevier
Background Spermidine (SPD) is a natural polyamine that shows beneficial effects on
osteoarthritis (OA). However, the effect of SPD on cartilage inflammation remains unknown …
osteoarthritis (OA). However, the effect of SPD on cartilage inflammation remains unknown …
[HTML][HTML] Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases
Y Chen, Y Gu, X Xiong, Y Zheng, X Liu, W Wang… - Biomedicine & …, 2022 - Elsevier
Cells communication in response to extracellular or biophysical stimulus relies on
elaborated systems of signal transduction. In the course of most signal pathway, the …
elaborated systems of signal transduction. In the course of most signal pathway, the …
Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
G Yang, K Wang, H Song, R Zhu, S Ding… - Frontiers in …, 2022 - frontiersin.org
Objectives: Osteoarthritis (OA) is a joint disease characterized by degeneration of joint
cartilage and is a significant cause of severe joint pain, physical disability, and impaired …
cartilage and is a significant cause of severe joint pain, physical disability, and impaired …
Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review
K Ning, Z Wang, X Zhang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Osteoarthritis is a chronic degenerative musculoskeletal disease characterized by
pathological changes in joint structures along with the incidence of which increases with …
pathological changes in joint structures along with the incidence of which increases with …
Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis
Y Gong, S Li, J Wu, T Zhang, S Fang, D Feng… - Burns & …, 2023 - academic.oup.com
Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in
the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common …
the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common …
The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses
YJ Shi, J Zhang, YW Wang, K Ding, Y Yan… - European Journal of …, 2022 - Elsevier
Spermidine alkaloids are a kind of natural products possessing an aliphatic triamine
structure with three or four methylene groups between two N-atoms. Spermidine alkaloids …
structure with three or four methylene groups between two N-atoms. Spermidine alkaloids …