Vimentin: Regulation and pathogenesis

D Paulin, A Lilienbaum, S Kardjian, O Agbulut, Z Li - Biochimie, 2022 - Elsevier
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

[HTML][HTML] Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2

M Kloc, A Uosef, J Wosik, JZ Kubiak, RM Ghobrial - Archives of virology, 2022 - Springer
The actin cytoskeleton and actin-dependent molecular and cellular events are responsible
for the organization of eukaryotic cells and their functions. Viruses, including severe acute …

[HTML][HTML] Age-specific nasal epithelial responses to SARS-CoV-2 infection

MNJ Woodall, AM Cujba, KB Worlock, KM Case… - Nature …, 2024 - nature.com
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk
of mortality in infected people over 85 years of age remains high. Here we investigate …

[HTML][HTML] Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection

S Zhao, Q Xu, Y Cui, S Yao, S Jin, Q Zhang… - Nature …, 2023 - nature.com
A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular
niches for replication. However, the role of intermediate filaments, which are crucial for …

Physicochemical nature of SARS-CoV-2 spike protein binding to human vimentin

P Deptuła, K Fiedoruk, M Wasilewska… - … Applied Materials & …, 2023 - ACS Publications
Vimentin, a protein that builds part of the cytoskeleton and is involved in many aspects of
cellular function, was recently identified as a cell surface attachment site for the severe acute …

Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication

Y Zhang, S Zhao, Y Li, F Feng, M Li… - Proceedings of the …, 2022 - National Acad Sciences
Emerging microbe infections, such as Zika virus (ZIKV), pose an increasing threat to human
health. Investigations on ZIKV replication have revealed the construction of replication …

[HTML][HTML] Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary cilia

V Lalioti, S González-Sanz, I Lois-Bermejo… - Scientific reports, 2022 - nature.com
Abstract The SARS-CoV-2 Spike protein mediates docking of the virus onto cells prior to
viral invasion. Several cellular receptors facilitate SARS-CoV-2 Spike docking at the cell …

[HTML][HTML] The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment

H Cessna, S Baritaki, A Zaravinos, B Bonavida - Cancers, 2022 - mdpi.com
Simple Summary Raf kinase inhibitor protein (RKIP) expression in cancer cells is
significantly reduced and promoting cancer cells growth and invasiveness. Overexpresssion …

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

Z Li, J Wu, J Zhou, B Yuan, J Chen, W Wu, L Mo, Z Qu… - MBio, 2021 - Am Soc Microbiol
Damage in COVID-19 results from both the SARS-CoV-2 virus and its triggered overactive
host immune responses. Therapeutic agents that focus solely on reducing viral load or …

[HTML][HTML] Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells

J Arrindell, P Abou Atmeh, L Jayet, Y Sereme, JL Mege… - IScience, 2022 - cell.com
Vimentin is a type III intermediate filament protein, widely expressed in mesenchymal cells.
Mainly located in the cytoplasm, vimentin can also appear at extracellular locations, where it …