The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …

During development of disease, complex intracellular signaling pathways regulate an
intricate series of events, including resistance to external toxins, the secretion of cytokines …

The polarization of macrophages into a regulatory-like phenotype and the production of IL-
10 plays an important role in the resolution of inflammation. We show in this study that PGE …

Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …

Fluorinated sulfinate salts RfSO2Na (Rf= CF2H, CF2Ph, and CH2F) have been prepared via
NaBH4-mediated reduction of the corresponding benzo [d] thiazol-2-yl sulfones, and their …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …