Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug
delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive …

Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …

Metal ions are important trace elements in the human body, which directly affect the human
metabolism and the regeneration of damaged tissues. For instance, the advanced …

Particle-based drug delivery systems have a demonstrated value in osteoarthritis treatment.
Research in this area trends to developing functional particles to improve the therapeutic …

Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

Regulating macrophage activation precisely is crucial in treating chronic inflammation in
osteoarthritis (OA). However, the stable pro-inflammatory state and deep distribution of …

As promising biomaterials, hydrogels are widely used in the medical engineering field,
especially in wound repairing. Compared with traditional wound dressings, such as gauze …

Growth factor therapy is an effective treatment strategy for bone repair. Research in this field
aims to develop functional biomaterials for delivering multiple growth factors in a temporally …

Poly (α-L-glutamic acid)(PGA) is a class of synthetic polypeptides composed of the
monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non …