Several clinical studies show a gender dimorphism of immune and organ responsiveness in
the susceptibility to and morbidity from shock, trauma, and sepsis. However, there are …

Background. Nonsteroidal agonists have been developed that selectively bind to and
activate estrogen receptor β (ERβ) rather than estrogen receptor a (ERα). ERβ is expressed …

Oestrogen protects the heart from ischaemic injury. The current study aims to characterise
two novel oestrogen receptor (ER) ligands, an ERα agonist ERA-45 and an ERβ antagonist …

The mechanisms underlying the age-dependent reversal of female cardioprotection are
poorly understood and complicated by findings that estrogen replacement is ineffective at …

To study the cell signaling events leading to 17β-estradiol (E2)-induced acute
cardioprotection, we subjected isolated rat hearts to three 5-min cycles of 10 μM E2 before …

Objective: To determine the effect of an estrogen receptor-β selective agent in experimental
models of systemic infection and sepsis. Design: WAY-202196, a nonsteroidal selective …

Estrogen and estrogen receptors (ERs) have been reported to play protective roles in
ischemia/reperfusion (I/R)-mediated injury, but the detailed mechanism remains to be fully …

Important sex differences in cardiovascular disease outcomes exist, including conditions of
hypertrophic cardiomyopathy and cardiac ischemia. Studies of sex differences in the extent …

In order to demonstrate the possible protective effects of estrogen receptor (ER)-α and ERβ
receptor subtypes in the pathogenesis of colonic and gastric oxidant damage, experimental …

Coronary heart disease is the main cause of death in women. Women during reproductive
years are at lower risk for coronary heart disease than men but this difference tends to …