Simple Summary Estrogens are steroid hormones that interact with nuclear receptors (ERα
and ERβ) and a membrane G-protein-coupled receptor (GPER) to regulate multiple …

Estrogen is a group of hormones that collaborate with the nervous system to impact the
overall well-being of all genders. It influences many processes, including those occurring in …

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as pollutants, can cause palpable
environmental and health impacts around the world, as endocrine disruptors, can disrupt …

The three major mitogen-activated protein kinase (MAPK) pathways (ERK1/2, p38, and
JNK/SAPK) are upstream regulators of the nuclear receptor superfamily (NRSF). These …

Post-translational and epigenetic regulation are important mechanisms controlling functions
of genes and proteins. Although the “classic” estrogen receptors (ERs) have been …

The G protein-coupled estrogen receptor 1 (GPER1) has been proposed to mediate rapid
responses to the steroid hormone estrogen. However, despite a strong interest in its …

We previously reported that piceatannol (PIC) had an anti-obesity effect only in
ovariectomized (OVX) postmenopausal obesity mice. PIC was found to induce the …

Cadmium (Cd) is a common environmental pollutant, while selenium (Se) can ameliorate
heavy metal toxicity. Consequently, this study aimed to investigate the protective effects of …

The role of estradiol (E2; an estrogen) in men needs to be more appreciated. In this review,
we address the clinical situations that allow the study of the clinical consequences of E2 …

Background The cyclin D1-cyclin dependent kinases (CDK) 4/6 inhibitor palbociclib in
combination with endocrine therapy shows remarkable efficacy in the management of …