[HTML][HTML] Biological effects of indole-3-propionic acid, a gut microbiota-derived metabolite, and its precursor tryptophan in mammals' health and disease

P Konopelski, I Mogilnicka - International journal of molecular sciences, 2022 - mdpi.com
Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

Gut microbiota and renin-angiotensin system: A complex interplay at local and systemic levels

K Jaworska, M Koper, M Ufnal - American Journal of …, 2021 - journals.physiology.org
Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …

Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats

P Konopelski, D Chabowski… - American Journal …, 2021 - journals.physiology.org
Recent evidence suggests that gut bacteria-derived metabolites interact with the
cardiovascular system and alter blood pressure (BP) in mammals. Here, we evaluated the …

Regulatory effect of gut microbes on blood pressure

D Yan, Y Sun, X Zhou, W Si, J Liu… - Animal Models and …, 2022 - Wiley Online Library
Hypertension is an important global public health issue because of its high morbidity as well
as the increased risk of other diseases. Recent studies have indicated that the development …

Lactobacillus group and arterial hypertension: A broad review on effects and proposed mechanisms

DD de Assis Gadelha, JL de Brito Alves… - Critical Reviews in …, 2024 - Taylor & Francis
Hypertension is the leading risk factor for cardiovascular diseases and is associated with
intestinal dysbiosis with a decrease in beneficial microbiota. Probiotics can positively …

Gut dysbiosis and hypertension: is it cause or effect?

KL Cook, MC Chappell - Journal of hypertension, 2021 - journals.lww.com
The worldwide incidence of hypertension is at pandemic proportions with an estimated one
in six adults exhibiting a sustained elevation in blood pressure [1]. Hypertension remains the …

Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome

VHD Guimarães, BM Marinho, D Motta-Santos… - The Journal of …, 2023 - Elsevier
Obesity and metabolic disorders represent a significant global health problem and the gut
microbiota plays an important role in modulating systemic homeostasis. Recent evidence …

[HTML][HTML] Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis

L Lin, S Xu, M Cai, S Li, Y Chen, L Chen, Y Lin - Plos one, 2024 - journals.plos.org
Background Numerous recent studies have found a strong correlation between intestinal
flora and the occurrence of hypertension. However, it remains unclear whether fecal …

[HTML][HTML] Microbiome-Based Therapeutics and Their Physiological Effects: Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic …

K Jaworska, M Koper, M Ufnal - American Journal of Physiology …, 2021 - ncbi.nlm.nih.gov
Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …