Scientific and clinical progress together with the development of effective novel therapeutic
options has engendered multiple important changes in the diagnosis and management of …

Urticaria is a common clinical condition presenting with wheals (hives), angioedema, or
both. Urticaria has a complex pathogenesis, along with a high disease burden, a significant …

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …

Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and
appropriate therapy are essential. This update and revision of the global guideline for HAE …

Angioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a
transient increase in vascular permeability. Angioedema can occur in the absence or …

Angioedema (AE), transient localized swelling due to extravasated fluid, is commonly
classified as mast cell mediator-induced, bradykinin-mediated or of unknown cause. AE …

Complement system aberrations have been identified as pathophysiological mechanisms in
a number of diseases and pathological conditions either directly or indirectly. Examples of …

The complement is a powerful cascade of the innate immunity and also acts as a bridge
between innate and acquired immune defence. Complement activation can occur via three …

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic
conditions from other confounding non-allergic clinical entities, and to identify the potential …

Recurrent episodes of bradykinin-mediated angioedema (Bk-AE) can associate with
acquired or hereditary conditions, the former most commonly developing secondarily to a …