Quantitation of cytomegalovirus: methodologic aspects and clinical applications

M Boeckh, G Boivin - Clinical microbiology reviews, 1998 - Am Soc Microbiol
Cytomegalovirus (CMV) is an important pathogen in transplant recipients and human
immunodeficiency virus (HIV)-infected individuals. Major progress has been made in …

Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms

C Gilbert, J Bestman-Smith, G Boivin - Drug resistance updates, 2002 - Elsevier
Nucleoside analogues such as acyclovir and ganciclovir have been the mainstay of therapy
for alphaherpesviruses (herpes simplex virus (HSV) and varicella-zoster virus (VZV)) and …

Resistance of human cytomegalovirus to antiviral drugs

A Erice - Clinical Microbiology Reviews, 1999 - Am Soc Microbiol
Resistance of cytomegalovirus (CMV) to antiviral agents is a well-recognized phenomenon
that has been observed in the laboratory and in the clinical setting. Infections caused by …

High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes

IL Smith, JM Cherrington, RE Jiles… - Journal of Infectious …, 1997 - academic.oup.com
Mutations in both the viral phosphotransferase gene, UL97, and the DNA polymerase gene,
UL54, have been shown to confer ganciclovir resistance to cytomegalovirus (CMV) …

Human cytomegalovirus resistance to antiviral drugs

C Gilbert, G Boivin - Antimicrobial Agents and Chemotherapy, 2005 - Am Soc Microbiol
Human cytomegalovirus (HCMV) infections are common and lead to lifelong infections. In
immunocompetent individuals, primary infections are mostly subclinical or they may be …

Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel

RJ Whitley, MA Jacobson, DN Friedberg… - Archives of internal …, 1998 - jamanetwork.com
Objective To provide recommendations for the treatment of acquired immunodeficiency
syndrome–related cytomegalovirus (CMV) end-organ diseases, including retinitis, colitis …

Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease

S Chou, G Marousek, S Guentzel… - Journal of Infectious …, 1997 - academic.oup.com
In a human immunodeficiency virus-infected subject, cytomegalovirus (CMV) isolated 9
months after the patient began oral ganciclovir prophylaxis was resistant to ganciclovir and …

Cytomegalovirus infection of the central nervous system.

P Griffiths - Herpes: the journal of the IHMF, 2004 - europepmc.org
Studies report that 40-100% of the general population are infected with cytomegalovirus
(CMV), a virus associated with severe neurological conditions, such as CMV encephalitis …

Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients

A Erice, C Gil-Roda, JL Pérez… - Journal of Infectious …, 1997 - academic.oup.com
Antiviral susceptibilities to ganciclovir, foscarnet, and cidofovir and sequencing of UL97 and
DNA polymerase were done on 23 cytomegalovirus (CMV) isolates from 10 …

Retinal and extraocular cytomegalovirus end-organ disease in HIV-infected patients in Europe: a EuroSIDA study, 1994–2001

I Yust, Z Fox, M Burke, A Johnson, D Turner… - European Journal of …, 2004 - Springer
This multicentre prospective cohort study by the EuroSIDA study group was designed to
determine the factors affecting the incidence of cytomegalovirus (CMV) end-organ disease …