Simple Summary Chemotherapy has been widely used in clinic to treat various types of
tumors, although severe side effects have been the most critical limitation of this treatment …

Interest in self-immolative chemistry has grown over the past decade with more research
groups harnessing the versatility to control the release of a compound from a larger …

Bioorthogonal chemistry provides a new avenue for disease treatment by generating
therapeutic agents in situ. However, two crucial issues have to be considered for future …

Pyroptosis is an inflammatory form of programmed cell death that holds great promise in
cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self …

Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …

Inducing pyroptosis in cancer cells holds great potential in cancer immunotherapy.
Lipopolysaccharide (LPS)-sensing noncanonical pathways are an important mechanism of …

Bioorthogonal chemistry reactions occur in physiological conditions without interfering with
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …

Tryptophan (Trp) plays a critical role in the regulation of protein structure, interactions and
functions through its π system and indole N–H group. A generalizable method for blocking …

Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of
programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to …

Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …