receptor antisense oligonucleotide administration into the cerebral ventricles reduced
baseline sympathetic nerve activity in rats with CHF while having no effect in normal rats. 36 …

One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to
the peripheral circulation and to the heart. A correlation between plasma norepinephrine …

Sympathetic activation is a consistent finding in the chronic heart failure (CHF) state. Current
therapy for CHF targets the renin-angiotensin II (ANG II) and adrenergic systems …

The control of sympathetic outflow in the chronic heart failure (CHF) state is markedly
abnormal. Patients with heart failure present with increased plasma norepinephrine and …

Blockade of the angiotensin II (ANG II) type 1 receptor (AT1) has been shown to restore
baroreflex sensitivity in rats and rabbits with experimental chronic heart failure (CHF) …