Discrete-event simulation (DES) is a stochastic modeling approach widely used to address
dynamic and complex systems, such as healthcare. In this review, academic databases …

Chimeric antigen receptor (CAR) T cells are changing the therapeutic landscape for
hematological malignancies. To date, all six CAR T cell products approved by the US Food …

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic approach
in the treatment of multiple myeloma, and the recent approval of the first two CAR T-cell …

Systemic lupus erythematous is a heterogeneous autoimmune disease with potentially
multiorgan damage. Its complex etiopathogenesis involves genetic, environmental, and …

The landscape of therapeutic options for B cell malignancies has fundamentally changed
with regulatory and marketing approval of chimeric antigen receptor (CAR)-engineered T …

Background The first-in-class approved BCMA CAR-T therapy was idecabtagene vicleucel
(ide-cel), approved in March 2021, for RRMM patients who progressed after 4 or more lines …

Decentralized manufacturing has the benefits of fast fulfillment, reducing risks of distant
delivery, and improving patient access to personalised regenerative medicine (PRM) …

Blood, tissue and cell establishments (BTCs) stand out in the management of donor
selection, procurement and processing of all types of substances of human origin (SoHO). In …

Traditional food supply chains are often centralised and global in nature, entailing
substantial resource consumption. However, in the face of growing demand for …

Background Cell viability is an important release criterion in the manufacturing of cell
therapy products. Low cell viability can have significant impact on product quality and …