Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Tumor metastasis is an important reason for the difficulty of tumor treatment. Besides the
tumor cells themselves, the tumor microenvironment plays an important role in the process …

The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …

During tumor evolution, cancer cells can acquire the ability to proliferate, invade neighboring
tissues, evade the immune system, and spread systemically. Tracking this process remains …

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the
main causes of cancer-related death, including in breast cancer. The tumor …

Bivalent chromatin is defined by the co-occurrence of otherwise opposing H3K4me3 and
H3K27me3 modifications and is typically located at unmethylated promoters of lowly …

The basis of the cancer stem cell concept had already been coined in the 19th century by
the time the German pathologists, Virchow and Cohnheim, proposed the 'embryonic origin of …

Intratumoral heterogeneity and cellular plasticity have emerged as hallmarks of cancer,
including pancreatic ductal adenocarcinoma (PDAC). As PDAC portends a dire prognosis, a …