Osteosarcoma is the most common primary bone tumor and represents a major therapeutic
challenge in medical oncology. While the use of aggressive chemotherapy has drastically …

The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers.
However, in contrast to the exon 1β-encoded N-terminal half of ARF, the function of the exon …

Abstract Background Human papillomavirus (HPV) DNA replication can be inhibited by the
cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits …

Adenovirus was first identified in the 1950s and since then this pathogenic group of viruses
has been explored and transformed into a genetic transfer vehicle. Modification or deletion …

Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …

Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer
effects by causing damage to cellular DNA. However, systemic treatment damages DNA not …

В статье анализируются данные современной литературы и результаты собственных
исследований о роли дисбаланса программированной клеточной гибели в …

В монографии рассматриваются актуальные вопросы современной медико-
биологической науки, касающиеся иммунологический аспектов формирования …

TBX2 is one of the family of genes encoding developmental transcription factors,
characterized by a 200 amino acid DNA binding domain (T-box), found to be related to …

Despite aggressive surgery, radiation therapy, and chemotherapy, glioblastoma multiforme
(GBM) is refractory to therapy, recurs quickly, and results in a median survival time of only 14 …