Preclinical large animal models of heart failure (HF) play a critical and expanding role in
translating basic science findings to the development and clinical approval of novel …

The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment
option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary …

Introduction Differential hypoxia is a pivotal problem in patients with femoral veno-arterial
(VA) extracorporeal membrane oxygenation (ECMO) support. Despite recognition of …

Extracorporeal life support (ECLS), or extracorporeal membrane oxygenation (ECMO) as it
is also known, has been used to support over 45,000 patients to date. Overall survival is …

Objectives Adult patients who have undergone the Fontan procedure are highly vulnerable
to gradual, progressive circulatory failure, and options to reverse this situation are few. A …

Background Previous attempts to support single ventricle circulation mechanically have
suggested that a custom-built assist device is needed to push, rather than pull, through the …

The number of patients with the failing Fontan physiology is increasing. We tested a novel in
situ microaxial pump (Impella) to support the failing atrio-pulmonary Fontan circulation in an …

Advances in surgical and medical care of children born with heart defects have led to the
emergence of a unique subgroup of young adults known as adults with congenital heart …

Objectives The Avalon Elite (Macquet, Rastatt, Germany) double-lumen cannula can provide
effective cavopulmonary assistance in a Fontan (total cavopulmonary connection) sheep …

An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist
device for adolescent and adult patients with dysfunctional F ontan physiology. Coupling …