Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor
positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant …

Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting
evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is …

Background: Key characteristics (KCs), properties of agents or exposures that confer
potential hazard, have been developed for carcinogens and other toxicant classes. KCs …

Endocrine disrupting compounds (EDCs) are prevalent and ubiquitous in our environment
and have substantial potential to compromise human and animal health. Amongst the …

Endometriosis is a common gynecological disease, that often leads to pain and infertility. At
present, the specific pathogenesis of endometriosis has not been clarified, but it may be …

Background A series of novel inflammation-related indexes has been confirmed to be
efficient indicators of human immune and inflammatory status, with great potential as …

Epigenetics modification such as DNA methylation can affect maternal health during the
gestation period. Furthermore, pregnancy can drive a range of physiological and molecular …

Cancer patients appear to be more likely to be diagnosed with coronavirus disease 2019
(COVID-19). This is supported by the understanding of immunometabolic pathways that …

We identified abnormally methylated, differentially expressed genes (DEGs) and pathogenic
mechanisms in different immune cells of RA and SLE by comprehensive bioinformatics …

Objectives Optic neuritis is (ON) is believed to be an immune-mediated disease; however,
the association between optic neuritis and autoimmune diseases remains unclear. This …